What is it about?
In interventional radiology, metallic or polymer-based implants are usually used to selectively occlude blood vessels (e.g., in cases of bleeding, aneurysms, or tumor embolization). These materials are mechanically stable but biologically inert and remain permanently in the body.
As part of a larger research project, a novel embolic vessel occlusion device based on natural structural proteins is being developed. The goal is to create a biointegrative, self-expanding biomaterial that can reliably occlude blood vessels after catheter-based implantation.
This master's project investigates initial material concepts and demonstrates the technical feasibility of a protein-based embolization system.
Project objective:
The aim of the work is to experimentally demonstrate technical feasibility of a self-expanding protein-based embolization plug. Protein-based materials can offer advantages over conventional implants, such as promoting blood clotting, high fluid absorption, swelling, and good biocompatibility and biodegradability.
The project will develop initial material prototypes and examine their basic function for vascular occlusion.
In this thesis:
- combination of literature analysis, material development, and laboratory work
- Development of concepts for a protein-based biomaterial for vascular occlusion
- Production and characterization of porous biomaterial structures (e.g., lyophilized protein matrices)
- Investigation of swelling, mechanical stability, and 3D behavior in a hydrated state
- Insight into the early development of minimally invasive medical devices
Possible Master-Profiles:
