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  2. Optimized Spray Drying Optimized Spray Drying

Optimized Spray Drying

The pharmaceutical industry works intensively on the development of new dosages forms for innovative active ingredients. One important research direction is the production of inhalable particles (diameter from one to three micrometers) through spray drying.

Brief information

School:

Engineering and Architecture

Status:

Completed

Period:

11.09.2008 - 31.12.2009

Overview

BÜCHI Labortechnik AG is a leading global supplier of spray drying systems for applications in research laboratories. In this project, an existing spray dryer for the production of inhalable particles from BÜCHI was optimized. The sub-processes of the atomization of the solution, the drying of the formed droplets or particles and the separation of the particles were examined theoretically and experimentally and then optimized.

The atomization and drying was analyzed via LDA/PDA laser measuring technology. With a parametric study, the optimum operating conditions for the production of the desired particles could be assessed. Another challenge is the separation of the particles in the gas cyclone. With the help of empirical models and numerical flow simulations, a new type of gas cyclone was developed for the separation of these ultra-fine particles. Compared to existing gas cyclones, this gas cyclone achieves 15%-30% higher separation efficiencies.

With the optimized spray dryer it is possible to produce inhalable particles with a yield of 90%. This enables a more cost-effective production of pharmaceutical active ingredients that results in drastically lower development costs for new types of medicaments.

BÜCHI Laborsprühtrockner B290, © BÜCHI Labortechnik AG
Bestimmung der Tropfengrösse und Tropfengschwindigkeit mit LDA/PDA-Lasermesstechnik., © Hochschule Luzern - Technik & Architektur
Bestimmung der Partikelgrösse mittels Laserbeugung (Sympatec Helos KR), © Hochschule Luzern - Technik & Architektur
Beispiel einer Partikelgrössenverteilung, © Hochschule Luzern - Technik & Architektur
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Facts

Type of project

Forschung

Internal organisations involved
  • CC Thermal Energy Systems and Process Engineering
External project partner
  • Büchi Labortechnik AG
Funding
  • Private / Stiftungen
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Persons involved: internal

Project manager
  • Beat Wellig

Brief information

School:

Engineering and Architecture

Status:

Completed

Period:

09/11/2008 - 12/31/2009

Project Head

Prof. Dr. Beat Wellig

Lecturer

+41 41 349 32 57

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