Overview
Autologous connective tissue grafts harvested from the palate are considered the clinical gold standard for augmenting peri-implant and periodontal soft tissues. However, they are associated with significant donor-site morbidity, postoperative pain, and limitations in the amount of tissue available for harvesting.
The aim of this interdisciplinary project is to develop a biointegrative, form-stable, and elastic protein-based soft-tissue substitute as a less invasive alternative for patients. Within a one-year feasibility study, suitable raw materials—including proteins such as collagen as well as hyaluronic acid and other biomaterials—are identified and processed into chemically and/or physically crosslinked matrix prototypes.
These prototypes are evaluated with respect to their structural properties, usability, and cellular biocompatibility. The project establishes the scientific and technological basis for a subsequent multi-year, externally funded research project, for example through the Swiss National Science Foundation (SNF), aimed at advancing the technology toward clinical translation.
